Hepatocyte-derived MASP1-enriched small extracellular vesicles activate HSCs to promote liver fibrosis.

Xianzhi LiuSiwei TanHuiling LiuJie JiangXing WangLeijia LiBin Wu

Published in: Hepatology (Baltimore, Md.) (2022)

ARRB1 up-regulates the release of hepatocyte-derived MASP1-enriched small EVs by regulating the autophagic-lysosomal/multivesicular body pathway and Rab27A. Hepatocyte-derived MASP1 activates HSCs to promote liver fibrogenesis through p38 MAPK/ATF2 signaling. Thus, MASP1 is a pivotal therapeutic target in liver fibrosis.

Keyphrases

liver fibrosis
liver injury
transcription factor