Pd0 -Catalyzed Four-Component Reaction of Aryl Halide, CO, N-Tosylhydrazone, and Amine.

A Pd0 -catalyzed four-component cascade reaction of an aryl halide, CO, an N-tosylhydrazone, and an amine affording α-amino ketone has been developed. This reaction involves a sequential carbonylation, metal carbene migratory insertion, and amination. Control experiments and DFT calculations further reveal the reaction sequence and chemoselectivity of individual components in this cascade process.