Modelling the effect of subcellular mutations on the migration of cells in the colorectal crypt.

Lotte B RomijnAxel A AlmetChin Wee TanJames M Osborne

Published in: BMC bioinformatics (2020)

Our framework allows us to investigate how subcellular mutations, i.e. knockouts and knockdowns, affect cell-level properties and the resultant migration of cells within epithelial tissues. In the context of the colorectal crypt, we see that mutations in APC can lead directly to mutant cell invasion.

Keyphrases

induced apoptosis
cell cycle arrest
gene expression
endoplasmic reticulum stress
cell death
single cell
stem cells
signaling pathway
mesenchymal stem cells
cell therapy
bone marrow
pi k akt