An innovative single-cell approach for phenotyping and functional genotyping of CAR NK cells.

Matthew Ryan SullivanMichael FinocchiaroYichao YangJudene ThomasAlaa AliIsabel KaplanYasmin AbdulhamidEden BobilevMichal ShefferRizwan Romee Tania Konry

Published in: Journal for immunotherapy of cancer (2024)

This study provides a new potential approach for enhanced early screening of immunotherapies to improve their development, with a highly relevant cell model to demonstrate. Additionally, our validation studies provided some potential insights into transcriptomic determinants influencing CAR NK cytotoxicity.

Keyphrases

single cell
nk cells
high throughput
rna seq
human health
cell therapy
risk assessment
gene expression
mesenchymal stem cells
bone marrow