Nanoparticle delivery of grape seed-derived proanthocyanidins to airway epithelial cells dampens oxidative stress and inflammation.
S CastellaniA TrapaniA SpagnolettaL di TomaT MagroneS Di GioiaD MandracchiaG TrapaniE JirilloMassimo ConesePublished in: Journal of translational medicine (2018)
SLN are a biocompatible drug delivery system for natural anti-oxidants obtained from grape seed in a model of oxidative stress in airway epithelial cells. They feature stability and long-term persistence inside cells where they release proanthocyanidins. These results could pave the way to novel anti-oxidant and anti-inflammatory therapies for chronic respiratory diseases.
Keyphrases
- oxidative stress
- induced apoptosis
- anti inflammatory
- diabetic rats
- dna damage
- ischemia reperfusion injury
- endoplasmic reticulum stress
- cell cycle arrest
- signaling pathway
- machine learning
- deep learning
- sentinel lymph node
- squamous cell carcinoma
- drug release
- radiation therapy
- drug delivery
- early stage
- cell proliferation
- pi k akt
- drug induced