Genotoxicity of the vegetables juice grown in garden built on the tailings coal deposits.
Jairo José ZoccheMiriam da Conceição MartinsPaula RohrAdriani Paganini DamianiKarina O TeixeiraGabriela D BorgesMaiellen M de JesusThais Ceresér VilelaVanessa Moraes de AndradePublished in: Archives of environmental & occupational health (2019)
The aim of the present study was to evaluate the genotoxic effect of lettuce (Lactuca sativa L.), beet (Beta vulgaris L.), broccoli (Brassica oleracea var. italica), and kale (Brassica oleracea var. acephala) grown in vegetable garden built on the deposits of coal tailings. For this, we used 72 healthy male Swiss albino mice that received juice from the vegetables in an acute or chronic treatment. Using comet assay, we determined that acute administration of the juices of all vegetables from the coal-mining area was genotoxic, and increased the DNA damage in the blood, liver, and cerebral cortex of mice. Therefore, the present data suggest that intake of vegetables cultivated over coal waste results in an increase in DNA damage in some organs; this situation may pose a risk to health.
Keyphrases
- heavy metals
- dna damage
- health risk assessment
- health risk
- particulate matter
- human health
- liver failure
- risk assessment
- oxidative stress
- respiratory failure
- drug induced
- dna repair
- high fat diet induced
- public health
- sewage sludge
- aortic dissection
- air pollution
- high throughput
- genome wide analysis
- electronic health record
- arabidopsis thaliana
- intensive care unit
- big data
- drinking water
- insulin resistance
- functional connectivity
- climate change
- metabolic syndrome
- physical activity
- transcription factor
- weight gain
- artificial intelligence
- skeletal muscle
- anaerobic digestion
- cerebral ischemia