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A child with Winchester syndrome responding to oral betamethasone and methotrexate.

Gaurav DashSwetalina PradhanUpasna SinhaRuchi Sinha
Published in: Pediatric dermatology (2024)
Winchester syndrome (WS) is a rare genetic disorder with a handful of cases reported to date. We report a 14-year-old male who presented with growth retardation, contracture of left lower limb due to thick indurated skin, hypertrichosis, and bilateral corneal opacity. There was complete improvement in joint contracture with oral betamethasone pulse and weekly oral methotrexate.
Keyphrases
  • lower limb
  • case report
  • high dose
  • blood pressure
  • genome wide
  • gene expression
  • dna methylation
  • copy number