IL-1β induces rod degeneration through the disruption of retinal glutamate homeostasis.

Hugo Charles-MessanceGuillaume BlotAude CouturierLucile VignaudSara TouhamiFanny BeguierLourdes SiqueirosValérie ForsterNour BarmoSébastien AugustinSerge PicaudJosé-Alain SahelAlvaro RendonAntje GroscheRamin TadayoniFlorian SennlaubXavier Guillonneau

Published in: Journal of neuroinflammation (2020)

Our study emphasizes the importance of inflammation in the deregulation of glutamate homeostasis and provides a comprehensive mechanism of action for IL-1β-induced rod degeneration.

Keyphrases

oxidative stress
optical coherence tomography
diabetic rats
high glucose
diabetic retinopathy