Serum ferritin and ECOG performance status predict the response and improve the prognostic value of IPSS or IPSS-R in patients with high-risk myelodysplastic syndromes and oligoblastic acute myeloid leukemia treated with 5-azacytidine: a retrospective analysis of the Hellenic national registry of myelodysplastic and hypoplastic syndromes.
Sotirios G PapageorgiouIoannis KotsianidisAnthi BouchlaArgyris SymeonidisAthanasios GalanopoulosNora-Athina ViniouEleftheria HatzimichaelTheodoros P VassilakopoulosDimitrios GogosAikaterini MegalakakiPanagiotis ZikosPanagiotis DiamantopoulosAlexandra KourakliPanagiota GiannouliaMenelaos PapoutselisElias PoulakidasMaria ArapakiAnna VardiAchilles AnagnostopoulosDespoina MparmparousiMaria PapaioannouEleni BouronikouMaria DimouHelen PapadakiPanayiotis PanayiotidisVasiliki PappaPublished in: Therapeutic advances in hematology (2020)
ECOG PS and SF levels > 520 ng/ml independently predict response to 5-AZA, OS and LFS. Their incorporation in the IPSS and IPSS-R scores enhances these scores' predictive power in 5-AZA-treated higher-risk MDS and oligoblastic AML patients.