Mutational profiling of mitochondrial DNA reveals an epithelial ovarian cancer-specific evolutionary pattern contributing to high oxidative metabolism.

Fanfan XieWenjie GuoXingguo WangKaixiang ZhouShanshan GuoYang LiuTianlei SunShengjing LiZhiyang XuQing YuanHuanqin ZhangXiwen GuJinliang XingShujuan Liu

Published in: Clinical and translational medicine (2024)

Our study presents a comprehensive delineation of EOC-specific evolutionary patterns of mtDNA mutations that aligned well with the specific mitochondrial metabolic remodelling, conferring novel insights into the functional roles of mtDNA mutations in EOC tumourigenesis and progression.

Keyphrases

mitochondrial dna
copy number
genome wide
oxidative stress
dna methylation
gene expression
single cell