Asymmetric activation of microglia in the hippocampus drives anxiodepressive consequences of trigeminal neuralgia in rodents.

These findings suggest that priming of microglia with ATP/P2X7R in the ipsilateral hippocampus drives pain-related anxiodepressive-like behaviors via IL-1β. An asymmetric role of the bilateral hippocampus in TN-induced anxiety and depression was revealed. The approaches targeting microglia and P2X7R signaling might offer novel therapies for trigeminal neuralgia-related anxiety and depressive disorder.