Recommended Definitions of Aggressive Prostate Cancer for Etiologic Epidemiologic Research.
Lauren M HurwitzIlir AgalliuDemetrius AlbanesKathryn Hughes BarrySonja I BerndtQiuyin CaiChu ChenIona ChengJeanine M GenkingerGraham G GilesJiaqi HuangCorinne E JoshuTimothy J KeySynnove KnutsenStella KoutrosHilde LangsethSherly X LiRobert J MacInnisSarah C MarktKathryn L PenneyAurora Perez-CornagoThomas E RohanStephanie A Smith-WarnerMeir J StampferKonrad H StopsackCatherine M TangenRuth C TravisStephanie J WeinsteinWu Lang PhDEric J JacobsLorelei A MucciElizabeth A PlatzMichael B Cooknull nullPublished in: Journal of the National Cancer Institute (2022)
We recommend that etiologic epidemiologic studies of prostate cancer report results for this definition of aggressive prostate cancer. We also recommend that studies separately report results for advanced category (T4 or N1 or M1), high-grade (Gleason score ≥8), and fatal prostate cancer. Use of this comprehensive set of endpoints will facilitate comparison of results from different studies and help elucidate prostate cancer etiology.