Integrin expression and adhesivity to fibronectin in primary acute myeloid leukemia cells: Impact of NPM1 and FLT3 mutations.

Kateřina KuželováAdam ObrJana MarkováZdenka Gašová

Published in: European journal of haematology (2020)

The integrin αVβ3 is expressed in particular on CD34+ cells with NPM1 mutation and might have a prognostic value in patients with mutated NPM1. FLT3-ITD is associated with lower cell adhesivity, especially in patients with less differentiated leukemias.

Keyphrases

acute myeloid leukemia
induced apoptosis
allogeneic hematopoietic stem cell transplantation
cell cycle arrest
endoplasmic reticulum stress
single cell
stem cells
cell proliferation
oxidative stress
binding protein
cell migration
tyrosine kinase
pi k akt
bone marrow