6-Thioguanine blocks SARS-CoV-2 replication by inhibition of PLpro protease activities.
Caleb D SwaimYi-Chieh PerngXu ZhaoLarissa A CanadeoHouda H HarastaniTamarand L DarlingAdrianus C M BoonDeborah J LenschowJon M HuibregtsePublished in: bioRxiv : the preprint server for biology (2020)
A repurposed drug that targets an essential enzymatic activity of SARS-CoV-2 represents a promising COVID-19 therapeutic.