RERE deficiency causes retinal and optic nerve atrophy through degeneration of retinal cells.

Published in: Developmental dynamics : an official publication of the American Association of Anatomists (2021)

We conclude that RERE is required to control the apoptosis of retinal cells in the developing retina, and that RERE deficiency results in the retina atrophy through degeneration of the retinal cells and optic nerve atrophy through the loss of RGCs.

Keyphrases

optic nerve
optical coherence tomography
cell cycle arrest
induced apoptosis
diabetic retinopathy
endoplasmic reticulum stress
cell death
oxidative stress
signaling pathway
cell proliferation