Association of thoracic spine deformity and cardiovascular disease in a mouse model for Marfan syndrome.
Rodrigo Barbosa de SouzaLuis Ernesto Farinha-ArcieriMarcia Helena Braga CatroxoAna Maria Cristina Rebelo Pinto da Fonseca MartinsRoberto Carlos TedescoLuis Garcia AlonsoIvan Hong Jun KohLygia V PereiraPublished in: PloS one (2019)
We show that mgΔloxPneo model mimics the vascular disease observed in MFS patients. Furthermore, the study indicates role of thoracic spine deformity in the development of aorta diseases. We suggest that degradation of support structures of the aortic wall; deficiency in the sustenance of the thoracic vertebrae; and their compression over the adjacent aorta resulting in disturbed blood flow is a triad of factors involved in the genesis of dissection/aneurysm of thoracic aorta.
Keyphrases
- aortic valve
- blood flow
- spinal cord
- pulmonary artery
- cardiovascular disease
- mouse model
- aortic dissection
- coronary artery
- end stage renal disease
- newly diagnosed
- ejection fraction
- chronic kidney disease
- type diabetes
- pulmonary hypertension
- high resolution
- prognostic factors
- peritoneal dialysis
- pulmonary arterial hypertension
- spinal cord injury
- metabolic syndrome
- case report
- abdominal aortic aneurysm