Whole blood RNA sequencing reveals a unique transcriptomic profile in patients with ARDS following hematopoietic stem cell transplantation.
Joshua A EnglertMichael H ChoAndrew E LambMaya ShumyatcherDiana Barragan-BradfordMaria C BasilAngelica HigueraColleen IsabelleMayra Pinilla VeraPaul B DieffenbachLaura E FredenburghJoyce B KangAmi S BhattJoseph H AntinVincent T HoRobert J SoifferJudie A HowrylakBlanca E HimesRebecca M BaronPublished in: Respiratory research (2019)
Our findings reveal significant differences in whole blood transcriptomic profiles of patients with non-HSCT ARDS compared to ARDS-HSCT patients and point toward different immune responses underlying ARDS and ARDS-HSCT that contribute to lung injury.
Keyphrases
- acute respiratory distress syndrome
- extracorporeal membrane oxygenation
- mechanical ventilation
- single cell
- immune response
- end stage renal disease
- rna seq
- hematopoietic stem cell
- ejection fraction
- newly diagnosed
- intensive care unit
- chronic kidney disease
- acute myeloid leukemia
- peritoneal dialysis
- genome wide
- gene expression
- dendritic cells
- patient reported outcomes
- patient reported