Understanding the evolving phenotype of vascular complications in telomere biology disorders.
Cecilia HiggsYanick J CrowDenise M AdamsEmmanuel ChangDon HayesUtz HerbigJames N HuangRyan HimesKunal JajooF Brad JohnsonSusan D ReynoldsYoshihiro YonekawaMary ArmaniosFarid BouladCourtney D DiNardoCarlo DufourFrederick D GoldmanShakila KhanChristian KratzKasiani C MyersGanesh RaghuBlanche P AlterGeraldine AubertSonia BhalaEdward W CowenYigal DrorMounif El-YoussefBruce FriedmanNeelam GiriLisa Helms GubaPayal P KhinchaTiffany F LinHilary LonghurstLisa J McReynoldsAdam NelsonTim OlsonAnne PariserRosario PeronaGhadir SasaKristen SchratzDouglas A SimonettoDanielle TownsleyMichael WalshKatherine StevensSuneet AgarwalAlison A BertuchSharon A Savagenull nullPublished in: Angiogenesis (2018)
Vascular complications such as bleeding due to gastrointestinal telangiectatic anomalies, pulmonary arteriovenous malformations, hepatopulmonary syndrome, and retinal vessel abnormalities are being reported in patients with telomere biology disorders (TBDs) more frequently than previously described. The international clinical care consortium of telomere-associated ailments and family support group Dyskeratosis Congenita Outreach, Inc. held a workshop on vascular abnormalities in the TBDs at the National Cancer Institute in October 2017. Clinicians and basic scientists reviewed current data on vascular complications, hypotheses for the underlying biology and developed new collaborations to address the etiology and clinical management of vascular complications in TBDs.