Retinol from hepatic stellate cells via STRA6 induces lipogenesis on hepatocytes during fibrosis.

Injoo HwangEun Ju LeeHyomin ParkDodam MoonHyo-Soo Kim

Published in: Cell & bioscience (2021)

Retinol from HSCs via STRA6 in response to injury with TIF1γ-reduction is taken up by hepatocytes via STRA6, leading to fat-deposition and damage, and liver fibrosis.

Keyphrases

liver fibrosis
induced apoptosis
liver injury
cell cycle arrest
oxidative stress
adipose tissue
drug induced
endoplasmic reticulum stress
cell death
skeletal muscle