Intratumoural immune cell landscape in germinoma reveals multipotent lineages and exhibits prognostic significance.

Hirokazu TakamiS FukushimaK AokiK SatomiK NarumiN HamaY MatsushitaK FukuokaK YamasakiTaishi NakamuraA MukasaN SaitoT SuzukiT YanagisawaH NakamuraK SugiyamaK TamuraT MaeharaM NakadaM NonakaA AsaiK YokogamiH TakeshimaT IuchiY KanemuraK KobayashiM NaganeK KurozumiK YoshimotoM MatsudaA MatsumuraY HiroseT TokuyamaT KumabeK UekiY NaritaS ShibuiY TotokiT ShibataY NakazatoR NishikawaM MatsutaniK Ichimuranull null

Published in: Neuropathology and applied neurobiology (2019)

The collective data strongly suggest that infiltrating immune cells play an important role in predicting treatment response. Further investigation should lead to additional categorization of germinoma to safely reduce treatment intensity depending on tumour/immune cell balance and to develop possible future immunotherapies.

Keyphrases

electronic health record
current status
big data
single cell
combination therapy
machine learning
artificial intelligence
deep learning