Association of DNA repair gene variants with colorectal cancer: risk, toxicity, and survival.

Hamideh SalimzadehElinor Bexe LindskogBengt GustavssonYvonne WettergrenDavid Ljungman

Published in: BMC cancer (2020)

Both SNPs in ERCC2 were associated with risk of CRC as well as toxicity during first line treatment. In addition, ERCC2- rs238406 was linked to OS in early stage CRC. The ERCC1-rs11615 variant was associated with toxicity during adjuvant chemotherapy. The results add support to previous findings that SNPs in ERCC1 and ERCC2 have a prognostic and predictive value in clinical management of CRC.

Keyphrases

dna repair
dna damage
early stage
oxidative stress
genome wide
dna damage response
copy number
dna methylation
oxide nanoparticles
gene expression
squamous cell carcinoma