The G1/S transition is promoted by Rb degradation via the E3 ligase UBR5.
Shuyuan ZhangLucas Fuentes ValenzuelaEvgeny ZatulovskiyJan M SkotheimPublished in: bioRxiv : the preprint server for biology (2023)
The E3 ligase UBR5 progressively reduces the concentration of the retinoblastoma protein Rb during G1 to drive proliferation.