Dysregulation of the actin scavenging system and inhibition of DNase activity following severe thermal injury.
R J DinsdaleJ HazeldineK Al TarrahP HampsonA DeviC ErmogenousA L BamfordJ BishopS WattsE KirkmanJ J Dalle LuccaM MidwinterT WoolleyM FosterJ M LordN MoiemenPaul HarrisonPublished in: The British journal of surgery (2019)
The results of this study suggest a novel biological mechanism for the accumulation of cfDNA following thermal injury by which high levels of actin released by damaged tissue cause a reduction in DNase activity. Restoration of the actin scavenging system could therefore restore DNase activity, and reduce the risk of cfDNA-induced host tissue damage and thrombosis.