Macrophage function in obesity-induced inflammation and insulin resistance.
Mario A R LauterbachFrank Thomas WunderlichPublished in: Pflugers Archiv : European journal of physiology (2017)
The steadily increasing obesity epidemic affects currently 30% of western populations and is causative for numerous disorders. It has been demonstrated that immune cells such as macrophages reside in or infiltrate metabolic organs under obese conditions and cause the so-called low-grade inflammation or metaflammation that impairs insulin action thus leading to the development of insulin resistance. Here, we report on data that specifically address macrophage biology/physiology in obesity-induced inflammation and insulin resistance.
Keyphrases
- insulin resistance
- adipose tissue
- metabolic syndrome
- type diabetes
- low grade
- high fat diet induced
- oxidative stress
- high fat diet
- diabetic rats
- skeletal muscle
- polycystic ovary syndrome
- high glucose
- glycemic control
- high grade
- big data
- deep learning
- weight gain
- bariatric surgery
- artificial intelligence
- machine learning