Alanylglutamine Relieved Asthma Symptoms by Regulating Gut Microbiota and the Derived Metabolites in Mice.
Shao-Kun LiuLi-Bing MaYu YuanXiao-Ying JiWen-Jin SunJia-Xi DuanQing-Ping ZengBinaya WastiBing XiaoJian-Fei ZhengPing ChenXu-Dong XiangPublished in: Oxidative medicine and cellular longevity (2020)
The results indicated that Alanylglutamine might be beneficial for asthma, and its effect was achieved through the regulation on microbiota and the derived metabolites. The therapeutic effects might be associated with AMPK, NF-κB, mTOR, and STAT3 signaling pathways. These findings will help identify effective therapeutic direction to alleviate allergic inflammation of the lungs and airways.
Keyphrases
- signaling pathway
- allergic rhinitis
- chronic obstructive pulmonary disease
- lung function
- ms ms
- oxidative stress
- cell proliferation
- pi k akt
- cystic fibrosis
- skeletal muscle
- epithelial mesenchymal transition
- high fat diet induced
- lps induced
- metabolic syndrome
- induced apoptosis
- depressive symptoms
- physical activity
- protein kinase
- endoplasmic reticulum stress
- atopic dermatitis