Prospective evaluation of the cardiac safety of HER2-targeted therapies in patients with HER2-positive breast cancer and compromised heart function: the SAFE-HEaRt study.
F LynceA BaracX GengC DangA F YuK L SmithC GallagherP R PohlmannR NunesP HerbolsheimerR WarrenM B SrichaiM HofmeyerA CunninghamP TimotheeF M AschA Shajahan-HaqM T TanC IsaacsSandra M SwainPublished in: Breast cancer research and treatment (2019)
This study provides safety data of HER2-targeted therapies in patients with breast cancer and reduced LVEF while receiving cardioprotective medications and close cardiac monitoring. Our results demonstrate the importance of collaboration between cardiology and oncology providers to allow for delivery of optimal oncologic care to this unique population.