The Resistance to Host Antimicrobial Peptides in Infections Caused by Daptomycin-Resistant Staphylococcus aureus.
Md Saruar BhuiyanJhih-Hang JiangXenia KostouliasRavali TheegalaGraham J LieschkeAnton Y PelegPublished in: Antibiotics (Basel, Switzerland) (2021)
Daptomycin is an important antibiotic for the treatment of infections caused by Staphylococcus aureus. The emergence of daptomycin resistance in S. aureus is associated with treatment failure and persistent infections with poor clinical outcomes. Here, we investigated host innate immune responses against clinically derived, daptomycin-resistant (DAP-R) and -susceptible S. aureus paired isolates using a zebrafish infection model. We showed that the control of DAP-R S. aureus infections was attenuated in vivo due to cross-resistance to host cationic antimicrobial peptides. These data provide mechanistic understanding into persistent infections caused by DAP-R S. aureus and provide crucial insights into the adaptive evolution of this troublesome pathogen.
Keyphrases
- staphylococcus aureus
- immune response
- methicillin resistant staphylococcus aureus
- dendritic cells
- biofilm formation
- machine learning
- toll like receptor
- mass spectrometry
- big data
- pseudomonas aeruginosa
- inflammatory response
- electronic health record
- artificial intelligence
- replacement therapy
- atomic force microscopy