Metabolomic profiles, polygenic risk scores and risk of rheumatoid arthritis: a population-based cohort study in the UK Biobank.

Xin-Yu FangJie ZhangTing-Ting QianPeng GaoQing WuQuan FangSu-Su KeRong-Gui HuangHeng-Chuan ZhangNi-Ni QiaoYin-Guang FanDong-Qing Ye

Published in: RMD open (2023)

Our findings suggested the metabolic profiles comprising multiple metabolic biomarkers contribute to capturing an elevated risk of RA, and the integration of genome-wide PRSs further improved risk stratification.

Keyphrases

rheumatoid arthritis
genome wide
disease activity
dna methylation
ankylosing spondylitis
interstitial lung disease
systemic lupus erythematosus
systemic sclerosis
idiopathic pulmonary fibrosis