SPP1 promotes Schwann cell proliferation and survival through PKCα by binding with CD44 and αvβ3 after peripheral nerve injury.

Jiang-Bo WangZhan ZhangJian-Nan LiTuo YangShuang DuRang-Juan CaoShu-Sen Cui

Published in: Cell & bioscience (2020)

These results suggested that SPP1 promoted proliferation and inhibited apoptosis of SCs through PKCα signaling pathway by binding with CD44 and αvβ3. This study provides a potential therapeutic target for improving peripheral nerve recovery.

Keyphrases

peripheral nerve
signaling pathway
cell proliferation
pi k akt
cell cycle arrest
oxidative stress
endoplasmic reticulum stress
epithelial mesenchymal transition
dna binding
cell cycle
cell death
nk cells
binding protein
induced apoptosis
transcription factor
human health