Activation of Angiopoietin-Tie2 Signaling Protects the Kidney from Ischemic Injury by Modulation of Endothelial-specific Pathways.

Yanyang LiPan LiuYalu ZhouHiroshi MaekawaJohn B SilvaMohammed Javeed AnsariKhaled BoubesYazan AliaDilip K DebBenjamin R ThomsonJing JinSusan E Quaggin

Published in: Journal of the American Society of Nephrology : JASN (2023)

Our data support a key role of the endothelium in development of IR-AKI, introduce Hepta-ANG1 as a putative new therapeutic biologic, and report creation of a model to explain how IRI reduces Tie2 signaling and how Tie2 activation protects the kidney.

Keyphrases

rheumatoid arthritis
acute kidney injury
nitric oxide
angiotensin ii
data analysis
cerebral ischemia