Sex differences in the transcriptome of extracellular vesicles secreted by fetal neural stem cells and effects of chronic alcohol exposure.
Dae D ChungAmanda H MahnkeMarisa R PinsonNihal A SalemMichael S LaiNatalie P CollinsAndrew E HillhouseRajesh C MirandaPublished in: Biology of sex differences (2023)
The EV transcriptome is distinctly different from, and more sex-variant than, the transcriptome of cell-of-origin NSCs. Ethanol, a common teratogen, results in dose-dependent sorting of RNA transcripts from NSCs to EVs which may reprogram the EV-mediated endocrine environment during neurogenesis.