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New approaches for the reliable in vitro assessment of binding affinity based on high-resolution real-time data acquisition of radioligand-receptor binding kinetics.

Markus ZeilingerFlorian PichlerLukas NicsWolfgang WadsakHelmut SpreitzerMarcus HackerMarkus Mitterhauser
Published in: EJNMMI research (2017)
Both kinetic binding approaches comprise tracer administration and subsequent binding to living cells, expressing the dedicated target protein. Therefore, the experiments resemble better the true in vivo physiological conditions and provide important markers of cellular feedback and biological response.
Keyphrases
  • living cells
  • binding protein
  • high resolution
  • fluorescent probe
  • dna binding
  • single molecule
  • machine learning
  • pet imaging
  • amino acid
  • deep learning
  • capillary electrophoresis
  • wild type