Dual latent tuberculosis screening with tuberculin skin tests and QuantiFERON-TB assays before TNF-α inhibitor initiation in children in Spain.
Joan Calzada-HernándezJordi AntonJavier Martín de CarpiBerta López-MontesinosInmaculada CalvoEster DonatEsmeralda NúñezJavier Blasco AlonsoMaría José MelladoFernando Baquero-ArtigaoRosaura LeisAna María Vegas-ÁlvarezMarta Medrano San IldefonsoMaría Del Carmen Pinedo-GagoFrancisco Javier EizaguirreAlfredo TagarroMarisol Camacho-LovilloBeatriz Pérez-GorrichoCésar Gavilán-MartínSara GuillénBelén Sevilla-PérezLuis Peña-QuintanaPablo Mesa-Del-CastilloClàudia FortunyMarc TebrueggeAntoni Noguera-JulianPublished in: European journal of pediatrics (2022)
• A dual screening strategy, using TST and an IGRA assay, identified more children with latent tuberculosis than either of the tests alone. • Identification and treatment of latent tuberculosis before initiation of anti-TNF-α therapy averted incident tuberculosis cases.