Epigenomic and somatic mutations of pituitary tumors with clinical and pathological correlations in 111 patients.

Federica GuaraldiLuca MorandiMatteo ZoliDiego MazzatentaAlberto RighiStefania EvangelistiFrancesca AmbrosiCaterina TononCaterina GianniniRicardo V LloydSofia Asioli

Published in: Clinical endocrinology (2022)

Somatic mutations and methylation levels of genes involved in cell proliferation/differentiation, miRNA/LncRNA-post-transcriptional regulators and targets of antineoplastic therapies are different in non-aggressive and in aggressive PAs/PitNETs. Methylation profile also varies according to gender. Combined genetic-epigenetic analysis, in association with clinico-radiological-pathological data, may be of help in predicting PA/PitNET behaviour.

Keyphrases

dna methylation
cell proliferation
genome wide
copy number
end stage renal disease
gene expression
newly diagnosed
transcription factor
prognostic factors
peritoneal dialysis
machine learning
big data
oxidative stress
signaling pathway
artificial intelligence
pi k akt
long noncoding rna
heat shock