Hydroxyurea for Children with Sickle Cell Anemia in Sub-Saharan Africa.
Mariane de MontalembertGeorge A TomlinsonThomas N WilliamsBrígida SantosPeter Olupot-OlupotAdam LaneBanu AygunSusan E StuberTeresa S LathamPatrick T McGannRussell E Warenull nullPublished in: The New England journal of medicine (2018)
Hydroxyurea treatment was feasible and safe in children with sickle cell anemia living in sub-Saharan Africa. Hydroxyurea use reduced the incidence of vaso-occlusive events, infections, malaria, transfusions, and death, which supports the need for wider access to treatment. (Funded by the National Heart, Lung, and Blood Institute and others; REACH ClinicalTrials.gov number, NCT01966731 .).