The pharmacokinetics and pharmacodynamics of single-dose and multiple-dose recombinant activated factor VII in patients with haemophilia A or B.

While TEG and TGA are not yet clinically predictive, both supported the PK results. Data suggest that, while a single dose of 270 μg kg-1 rFVIIa provides slightly higher haemostatic potential than the multiple-dose regimen of 3×90 μg kg-1 , the latter results in prolonged activity levels compared with a higher single dose.