Cytotoxicity properties of plant-mediated synthesized K-doped ZnO nanostructures.
Mojtaba HaghighatHajar Q AlijaniMasoomeh GhasemiSajad KhosraviFariba BorhaniFatemeh SharifiSiavash IravaniKazem NajafiMarcos A L NobrePublished in: Bioprocess and biosystems engineering (2021)
In this study, potassium-doped zinc oxide nanoparticles (K-doped ZnO NPs) were green-synthesized using pine pollen extracts based on bioethics principles. The synthesized NPs were analyzed using X-ray diffraction (XRD), inductively coupled plasma atomic emission spectroscopy (ICP-AES), scanning electron microscopy (SEM), energy-dispersive X-ray analysis (EDXA), and transmission electron microscopy (TEM). The cytotoxicity of these nanoparticles (NPs) on normal macrophage cells and cancer cell lines was evaluated. In the same concentrations of K-doped ZnO and pure ZnO NPs, K-doped ZnO NPs demonstrated higher toxicity. The results confirmed that the doped potassium could increase cytotoxicity. The IC50 of K-doped ZnO NPs, pure ZnO NPs, and the examined control drug were 497 ± 15, 769 ± 12, and 606 ± 19 µg/mL, respectively. Considering the obtained IC50 of K-doped ZnO NPs, they were more toxic to the cancer cell lines and had less cytotoxicity on normal macrophage cells.
Keyphrases
- quantum dots
- oxide nanoparticles
- electron microscopy
- visible light
- high resolution
- room temperature
- induced apoptosis
- squamous cell carcinoma
- mass spectrometry
- magnetic resonance imaging
- cell proliferation
- cell cycle arrest
- ionic liquid
- adipose tissue
- highly efficient
- magnetic resonance
- reduced graphene oxide
- ms ms
- cell death
- solid phase extraction
- data analysis