Impact of delisting high-strength opioid formulations from a public drug benefit formulary on opioid utilization in Ontario, Canada.
Diana MartinsWayne KhuuMina TadrousDavid N JuurlinkMuhammad M MamdaniJ Michael PatersonTara Gomesnull nullPublished in: Pharmacoepidemiology and drug safety (2019)
The delisting of publicly-funded, high-strength opioids was accompanied by changes in funding source and small reductions in the weekly median daily doses dispensed. Although observed dose reductions of less than 1 MME weekly are likely not clinically relevant, safety implications of these changes require further monitoring.