Outcome of SARS-CoV-2 Infection in 121 Patients with Inborn Errors of Immunity: A Cross-Sectional Study.
Ekaterini Simões GoudourisFernanda Pinto-MarizLeonardo Oliveira MendonçaCarolina Sanchez ArandaRafaela Rolla GuimarãesCristina KokronMyrthes Anna Maragna Toledo BarrosFlavia A A CarvalhoMaria Luiza Oliva AlonsoFernanda MarcelinoSolange Oliveira Rodrigues ValleSérgio Duarte Dortas JúniorIrma Douglas Paes BarretoJanáira Fernandes Severo FerreiraPersio Roxo-JuniorAlmerinda Maria do Rego SilvaFernanda Lugão CampinhosCarmem Maria Sales BonfimGisele LothJuliana Folloni FernandesJulia Lopes GarciaAlbertina CapeloOlga Akiko TakanoMaria Isabel Valdomir NadafEliana C ToledoLuciana Araújo Oliveira CunhaRegina Sumiko Watanabe Di GesuLaire SchidlowskiPriscilla Filippo Alvim de Minas SantosDaniélli C Bichuetti-SilvaGustavo SoldateliNatasha Rebouças FerraroniEllen de Oliveira DantasSimone PestanaEli MansourRaisa Gusso UlafCarolina PrandoAntonio Condino-NetoAnete Sevciovic GrumachPublished in: Journal of clinical immunology (2021)
The outcome was mild in most patients, but the Case Fatality Ratio was higher than in the general population. However, the type of IEI was not a determining factor for severity, except for complement deficiencies linked to milder COVID-19. The severity of SARS-CoV-2 infection seems to be more related to older age, a higher number of comorbidities and type of comorbidities (bronchiectasis and cardiopathy).