Etrolizumab-s Does Not Induce Residual Trafficking of Regulatory T Cells.

Anna SchwedaEmily BeckerMaximilian WiendlRaja AtreyaImke AtreyaTanja M MüllerMarkus F NeurathSebastian Zundler

Published in: Inflammatory bowel diseases (2022)

Etrolizumab does not seem to induce notable residual trafficking of Treg cells. Thus, the Teff overweight in the inflamed gut might persist despite reduced overall T cell recruitment. This might be one piece of the puzzle to explain recent clinical results in phase 3.

Keyphrases

regulatory t cells
induced apoptosis
dendritic cells
cell cycle arrest
physical activity
weight gain
oxidative stress
endoplasmic reticulum stress
immune response
pi k akt