Clinical implications of AR alterations in advanced prostate cancer: a multi-institutional collaboration.
Zeynep B ZenginNicholas C HendersonJoseph J ParkAlicia AliCharles NguyenClara HwangPedro C BarataMehmet A BilenLaura S GrahamGeorge MoDeepak KilariAbhishek TripathiMatthew Kyle LabriolaShoshana RothsteinRohan GarjeVadim S KoshkinVaibhav G PatelMichael Thomas SchweizerAndrew J ArmstrongRana R McKayAjjai AlvaTanya Barauskas DorffPublished in: Prostate cancer and prostatic diseases (2024)
In this real-world clinicogenomics database-driven study we explored the development of AR alterations and their association with ARTA treatment outcomes. Our study showed that AR amplifications are associated with longer time to progression on first ARTA treatment. Further prospective studies are needed to optimize therapeutic strategies for patients with AR alterations.