Identification and in vivo characterization of a brain-penetrating nanobody.

Y WoutersT JaspersB De StrooperMaarten Dewilde

Published in: Fluids and barriers of the CNS (2020)

This method led to the discovery of an anti-transferrin receptor nanobody that can reach the brain via receptor-mediated transcytosis after peripheral administration. This method could be used to assess novel proteins for brain-penetrating capabilities using a target-engaging readout.

Keyphrases

resting state
white matter
functional connectivity
small molecule
binding protein
subarachnoid hemorrhage