Use of Methotrexate in Girls and Women of Childbearing Age, Occurrence of Methotrexate-Exposed Pregnancies and Their Outcomes in Germany: A Claims Data Analysis.

Nadine Wentzell Bianca Kollhorst Jonas Reinold Ulrike Haug

Published in: Clinical drug investigation (2022)

In Germany, the use of methotrexate in women of childbearing age has substantially increased since 2004. Despite the known teratogenic effect, there was a considerable number of exposed pregnancies. Also, malformations likely associated with methotrexate and thus avoidable were observed.

Keyphrases

high dose
data analysis
pregnancy outcomes
polycystic ovary syndrome
risk assessment
gestational age
pregnant women
low dose
type diabetes
cervical cancer screening