Administration and effects of beta blockers and oxandrolone in severely burned adults: a post hoc analysis of the RE-ENERGIZE trial.

Gabriel HundeshagenElisabeth BlearsViktoria MertinAndrew G DayAlen PalackicChristian TapkingValentin HaugUlrich KneserBjörn BliesenerAdriana C PanayiAriel AballayFrancois DepretChristian StoppeDaren K Heyland

Published in: Burns & trauma (2024)

The use of OX, BB and BBOX is common within the adult burn patient population, with its use varying considerably across sites worldwide. Our findings found mixed associations between outcomes and the use of BB and OX in adult burn patients, with lower acute and 6-month-mortality with BB and longer times to discharge with OX. Further research into these pharmacological modulators of the pathophysiological response to severe burn injury is indicated.

Keyphrases

growth factor
wound healing
recombinant human
liver failure
low density lipoprotein
small molecule
drug induced
case report
clinical trial
study protocol
respiratory failure
phase iii
early onset
angiotensin converting enzyme
intensive care unit
type diabetes
risk factors
metabolic syndrome
skeletal muscle