Replication-Based Rearrangements Are a Common Mechanism for SNCA Duplication in Parkinson's Disease.

Soo Hyun SeoAlbino BacollaDallah YooYoon Jung KooSung Im ChoMan Jin KimMoon-Woo SeongHan-Joon KimJong-Min KimJohn A TainerSung Sup ParkJi Yeon KimBeomseok Jeon

Published in: Movement disorders : official journal of the Movement Disorder Society (2020)

Our study has determined that homologous recombination mechanisms involving repetitive elements are not the main cause of the duplication of SNCA. The presence of microhomology at the junctions and their position within stem-loop structures suggest that replication-based rearrangements may be a common mechanism for SNCA amplification. © 2020 International Parkinson and Movement Disorder Society.

Keyphrases

dna repair
dna damage
high frequency
high resolution
single molecule
oxidative stress
nucleic acid