Analysis of changes in the action potential morphology of the mouse sinoatrial node true pacemaker cells during ontogenetic development in vitro and in silico.
Alexander RyvkinArseniy FurmanElena LebedevaMikhail A GonotkovPublished in: Developmental dynamics : an official publication of the American Association of Anatomists (2024)
density from E12.5 to adult leads to depolarization of MDP to the voltage range in which calcium currents are activated, thereby shifting the balance from the "membrane-clock" to the "calcium-clock."