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Charting a New Path Towards Degrading Every Protein.

Behnam Nabet
Published in: Chembiochem : a European journal of chemical biology (2020)
Strategies to directly alter protein abundance such as small-molecule-induced targeted protein degradation (TPD) are innovative pharmacological modalities with promising clinical potential. Herein, I describe my experience with the development of the degradation tag (dTAG) system, which is a chemical biology strategy to induce rapid and precise degradation of any target protein. Open-source collaborative discovery has been critical for advancing the versatility and accessibility of the dTAG system and will be necessary to understand the benefits and limits of TPD-based strategies in the clinic.
Keyphrases
  • small molecule
  • protein protein
  • primary care
  • single cell