Methylmalonic acidemia triggers lysosomal-autophagy dysfunctions.

Michele CostanzoArmando CeveniniLaxmikanth KolliparaMarianna CaterinoSabrina BiancoFrancesca PirozziGianluca ScerraMassimo D'AgostinoLuigi Michele PavoneAlbert SickmannMargherita Ruoppolo

Published in: Cell & bioscience (2024)

Defective homeostatic mechanisms in the regulation of autophagy and lysosome functions have been demonstrated in MUT-deficient cells. Our data prove that MMA triggers such dysfunctions impacting on autophagosome-lysosome fusion and lysosomal activity.

Keyphrases

induced apoptosis
endoplasmic reticulum stress
cell death
cell cycle arrest
signaling pathway
fluorescent probe
oxidative stress
living cells
electronic health record
big data
cell proliferation