Targeting cathepsin B by cycloastragenol enhances antitumor immunity of CD8 T cells via inhibiting MHC-I degradation.

Guoliang DengLisha ZhouBinglin WangXiaofan SunQinchang ZhangHongqi ChenNing WanHui YeXiaoqi WuDongdong SunYang SunHaibo Cheng

Published in: Journal for immunotherapy of cancer (2022)

Our data reported for the first time that cathepsin B downregulation confers antitumor immunity and explicates the antitumor mechanism of natural product CAG.

Keyphrases

signaling pathway
cell proliferation
drug delivery
artificial intelligence
deep learning