Experimental validation and molecular docking to explore the active components of cannabis in testicular function and sperm quality modulations in rats.

Charles Obiora NwonumaVictoria C NwatuGomaa Mostafa-HedeabOluyomi S AdeyemiOmokolade O AlejolowoOluwafemi Adeleke OjoSylvanus A AdahOluwakemi J AwakanCharles E OkolieNnaemeka Tobechukwu AsogwaInemesit A UdofiaGodshelp O EgharevbaNada H AljarbaSaad AlkahtaniGaber El-Saber Batiha

Published in: BMC complementary medicine and therapies (2022)

The antioxidant effects of the flavonoids in the ethanolic extract of cannabis may have protected testicular and sperm cells from oxidative damage. Biochemical processes and histopathological morphology were preserved by cannabis. The docking prediction suggests that the bioactive principle of cannabis may activate the androgenic receptors. The androgenic receptor modulation may be attributed to silymarin and quercetin.

Keyphrases

molecular docking
molecular dynamics simulations
oxidative stress
germ cell
anti inflammatory
molecular dynamics
binding protein